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gb88Derivatives of GB88 (3) suggest that all four of its components bind at distinct PAR2 sites with the isoxazole, cyclohexylalanine,B ) PAR2 antagonist GB88 (1.6 Ϯ 0.5 ␮ M) was 1000-fold more potent than ENMD-1068 (1.2 Ϯ 0.4 mM) in preventing trypsin-induced intracellular calcium release ([Ca 2 ϩ ] i ) in HMDMs ( n ϭ