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pede4dPharmacological phosphodiesterase 4D (PDE4D) inhibition shows therapeutic potential to restore memory function in Alzheimer's disease (AD), but will likely evoke adverse side effects. AsThe PDE4 family contains four genes (PDE4A to PDE4D), only PDE4A, PDE4B, and PDE4D are expressed in the heart, each of which regulates different cAMP-dependent